graviola for hepatic affections

Annona muricata is a shrub of approximately 5 feet tall with large waxy leaves, always green. It is widespread in warm areas of South and North America, including the Amazon forests. Is also called the Graviola, Soursop, Guanabana or Sitaphala. Produces large fruit, 15-20 cm, heart-shaped, light green in color towards the yellowish  with white core, edible.
The leaves and fruits are used by indigenous peoples of a long time as remedies for many diseases. In the Peruvian Andes, the tea of Annona leaf  is used as mucosal antiinflammatory in affections of nasal-pharyngeal and bronchitis while crushed seeds are used as antiparasitic. In the Peruvian Amazon region the bark from this shrub, roots and leaves are used for treatment of diabetes and as a sedative and spasmolytic. Some tribes in Guyana use tea of leaf and of bark  as a sedative and as cardiac tonic.
In the Brazilian region of the Amazon , the natives used tea from the leaves of Annona muricata for liver disorders and oil from the leaves and unripe fruits mixed with olive oil for the treatment of neuralgias and rheumatoid arthritis. In Jamaica and Haiti juice from fruits is used to treat fever, parasites and diarrhea, as well as lactagog; the bark and leaves are used there for various of cardiac conditions, flu, asthma, hypertension, parasites and difficult births.
It should be noted that modern medicine has not yet managed to confirm or refute all these actions and effects of this plant, such as it is used by indigenous peoples that we talked about above.
Were made some research to identify the active compounds of the Annona muricata and Annona atemoya (a close relative with similar effects) and therapeutic effects of those compounds. In fact, research of this plant began in 1940 and in 1976 was introduced in the program of identification that possible anticancer substances by the Study Cancer Institute (NCI U.S.). A large part of research have focused on a class of substances called acetogenine annonacee. The Graviola produces these substances in the leaves, bark and seeds. Have been identified 3 compounds with the action of anti-cancer with selective action on the tumor cells without affecting healthy cells of the body. Has been made and published at least 8 clinical studies. Some acetogenine have demonstrated a strong anti-cancer activity at very low doses, a part per million. In 1998 were published the results of a further four clinical studies that proven efficacy of substances extracted from the Graviola for the following types of cancer: lung cancer, breast cancer, prostate adenocarcinoma, pancreatic cancer, colon adenocarcinoma, lymphoma, breast adenocarcinoma many -resistant and liver cancer.
Bullatacina an isolated acetogenina from the atemoya Annona was studied by Chih in 2001 for its cytotoxic effects on the cancer cells of hepatic origin. Microscopy studies showed that the cytotoxic effect of bullatacinei on the cancer cells are due to induction of apoptosis. Was noted inhibition of electron transport chain in the mitochondria (Ahammadsahib, 1993) and inhibition of the activity NADH oxidase (Morre, 1995). It is also inhibited increase of cancer cell by inhibiting oxidative phosphorylation and decrease in level of ATP, the main energy molecule of cells.
Other isolated acetogenine from Annona muricata, for example muricinele AG, muricatetrocinele A and B, lungifolicina, corrosolina and corrosolona,  have proved extremely cytotoxic to liver cancer cells (Chang and Wu, 2001). These studies and observations make that preparation from various species of Annona be recommended as anti-hepatocarcinogenic remedies.
Dosage and administration:
In the normal way, total dose is 5-7 grams per day, divided into 3-4 doses throughout the day. It can do usual infusion and drink 2-3 cups a day. Also, it is equally efficient and the tincture made 4:1 (one part of plant in 4 parts alcohol 95%, leaving at least 7 days)of which is consumed 2-4 ml 3 times a day.
Contraindications:
The Graviola has proven to be a stimulant of uterine contractions and is therefore contraindicated in pregnant women.
The Graviola lowers blood pressure and is therefore contraindicated for hypotensive individuals. Persons undergoing a medicinal treatment for hypertension should consult their doctor before using Graviola.
Taken long term, Graviola destroy intestinal bacterial flora, due to its powerful antibacterial effect, so it is recommended the consumption of probiotics (yogurt, etc..) during treatment with any preparation of Annona.
Very large doses could induce to some people feeling sick. Slightly decrease your dose if you have such of sensation.
The persons who use antidepressant medications such as MAO inhibitors (monoamine oxidase) have to consult with your doctor before using Graviola. If it appears feeling of drowsiness decrease the dose of Graviola.
Like the interactions with medications, it is possible that Graviola to potentiate hypotensive effect of antihypertensive medications and to potentiate the sedative effect of antidepressant medicines such as MAO inhibitors.